61: Estimation of D-Dimer in Different Stages of Pregnancy

October 24, 2009

An Observational Study: Estimation of D-Dimer in Different Stages of Pregnancy and its Association with High Risk Pregnancy, DIC, Venous Thromboembolic Disease (VTE) and Pregnancy Lost ($62,690)

Dr A Khalafallah.

This study is considered the first study in Australia setting the normal reference range for D-Dimer, which is the end product of fibrin/fibrinogen during pregnancy. To date there are no previous studies performed in Australia in this concern, so that we are aiming that this study will be a reference study for Tasmania and Australia.

This observational study does not include any additional risks on pregnancy either on foetus or mothers as it analyses only blood, which will be taken during normal routine blood tests in the regular antenatal visits. We are looking forward to include 1000 pregnant women in this study.

A previous study performed in the UK showed that approximately 10% of investigated women during pregnancy have unexplained high D-Dimer level above the reference range for pregnancy. Therefore we are aiming to observe any correlation between high D-Dimer levels and high risk pregnancy like pregnancy loss, occurrence of venous thrombosis (clots) and other complications of pregnancy eg pre-eclampsia, HELLP syndrome etc.

Certainly this will reflect positively in understanding different causes of high risk pregnancy in correlation to high D-Dimer level and possibly to provide a very safe method for early detection of thses problems. We cannot over-emphasise how this is important in conducting the appropriate management and medical intervention or treatment if necessary.

Moreover, we are aiming to improve health care for Launceston/Tasmanian wormen and in the interest of the local community.

We are aiming to publish the data of this research in reputable international journals in the name of Clifford Craig Medical Research Trust. Tproject is involving students from University of Tasmania to promote and enhance their research capabilities and possibly to accomplish their scientific degrees.